The Correlation between Interleukin 33 and Psoriasis: A Systematic Review and Meta-Analysis
نویسندگان
چکیده
Psoriasis is a common genetic autoimmune disorder with global prevalence of 2–3%. The clear pathogenesis psoriasis not fully understood, but hyperproliferation and inflammation the epidermis marked infiltration immune cells have been indicated in such producing different types cytokines- interleukin. As new member IL-1 cytokine family, some research, IL-33 has linked showing high serum concentration human psoriatic plaques compared to normal healthy skin. Despite this, association between clear. Herein, this review, we aim investigate correlation levels psoriasis. We conducted meta-analysis using fixed or random-effects models calculate pooled standard mean differences. found that were reported 0.35 pg/mL 586 group 0 87.7 control group. Out five, four individual studies included analysis statistically significant differences levels, estimate (SMD = 0.340 95% CI: −0.308 0.988), however, did indicate relation This revealed no difference population comparison controls. may be because include any animal studies, lab-based other markers mixed together, cases diseases together. However, further research warranted confirm as limited by low-quality observational nature studies.
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ژورنال
عنوان ژورنال: Dermato
سال: 2023
ISSN: ['2673-6179']
DOI: https://doi.org/10.3390/dermato3010002